ACE
Angiotensin converting enzyme
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Product description:
Angiotensin-converting enzyme (ACE) is a pivotal component of the renin-angiotensin system (RAS)
and plays a critical role in circulatory homeostasis by causing blood vessels to constrict by
converting angiotensin I to angiotensin II. This enzyme is also regulated in glucose metabolism
by bradykinin, which induces glucose uptake by muscle cells. In addition, local RAS in a variety
of tissues, promote cell growth in diverse tissues, including in lung and skeletal muscles. ACE
inhibitors are widely used as pharmaceutical drugs for the treatment of cardiovascular diseases
such as hypertension.
Increased amounts of ACE often correlate to the presence of granulomas secondary to sarcoidosis,
an idiopathic condition that often affects the lungs, eyes, skin, nerves, liver and heart. About
50-80 % of patients with active sarcoidosis will have elevated levels of ACE. Test for ACE is
primarily ordered to help diagnose and monitor
